Added: Dewight Acton - Date: 06.08.2021 03:09 - Views: 40717 - Clicks: 794
Since the first officially reported case of the coronavirus disease COVID in late December, in Wuhan, China, the outbreak has evolved into a global public health crisis with an extensive of infected patients, causing devastating death toll all over the world 1. So far, the COVID pandemic Xuzhou sex contacts still ongoing and the causing virus SARS-CoV-2 is under extensive investigation in terms of its transmission routes 2 - 4infection mechanisms 5genomic evolution 6and environmental viability 7.
Although there have been tens of millions of confirmed cases, investigations of the disease are still not adequate and more clinical reports are urgently needed to share with medical staffs all over the world. Xuzhou is a prefecture-level city with around 10 million residents and is around km away from Wuhan. After hospitalization, all of the infected patients have been discharged home and are recovering from the disease.
However, asymptomatic infection and imported cases have been emphasized by the central and local governments as the potential risks for the second wave of outbreak. In this study, we performed a complete single-center retrospective analysis of a group of 25 patients with COVID disease in terms of epidemiological data, laboratory tests, clinical outcomes, radiological features, and medical treatments. This descriptive study gives an overall clinical understanding of the COVID patients in a prefecture-level city and provides a valuable experience in the prevention and treatment of COVID disease in China.
Only patients with a laboratory confirmed infection were enrolled in this study. Twenty-five patients were admitted to the affiliated hospital of Xuzhou Medical University from January 26, to February 13, These patients were retrospectively and consecutively analysed in this study. Standardised case report form was used to collect clinical data such as laboratory tests, clinical outcomes, chest CT, and medical treatments. If information was not clear, medical staff in the hospital contacted patients for clarification.
The present study was performed in accordance with the Helsinki Declaration as revised in and was approved by the Ethics Committee of the Affiliated Hospital of Xuzhou Medical University No. Written informed consent was obtained from participants or their families, retrospectively.
Confirmed cases were those with positive. Nucleocapsid N gene and open reading frame lab ORF1ab gene were amplified for detection of the virus. Laboratory diagnoses including routine blood test RBTcomprehensive metabolic panel CMPinfection test, and coagulation factors were performed for the clustered cases at the Department of Laboratory Medicine, the Affiliated Hospital of Xuzhou Medical University. Details of test dates and values are recorded in online table Table S2. Chest CT scanning were performed for all patients except for case No.
XYFY due to pregnancy. Treatment schemes for all patients were Xuzhou sex contacts in online table Table S3 and illustrated in Figure S1 except for case No. This is, patients were discharged when their body temperatures returned to normal for more than 3 consecutive days with improved respiratory symptoms, and pulmonary imaging shows ificant resolution of inflammation.
Meanwhile, nucleic acid detection for the pathogen SARS-CoV-2 need to be negative for two consecutive tests with at least 1 day apart. Data visualization and statistical analyses were performed with R package. All the continuous measurement is present as an average with standard deviations when comparing the indices inn different groups while swarm plot and time series curves were used for data visualization. Classification variable is presented in percentage. Laboratory parameters outside the normal range were marked out in plots. This is a retrospective study and no patients were involved in the study de, setting the research Xuzhou sex contacts, or the outcome measures directly.
No patients were asked to advise on interpretation or writing up of. In this study, we performed a single-center retrospective analysis of 25 COVID patients admitted to the affiliated hospital of Xuzhou Medical University. Professions of these patients are diverse, including farmers, teachers, workers, and hospital cleaners, etc. Fifteen patients are male while 10 patients are female. Age distribution ranges from 21 to 80 years old with the average age at 45 years old and the standard deviation of Three cases were imported, and 6 clustered cases were identified.
From symptom onset to confirmed infection, the average time is 6. Among the 25 patients, 3 patients had very mild conditions, 2 patients were in severe conditions while other Xuzhou sex contacts were in regular conditions. After hospitalization and medical treatments, all the patients were discharged home. Interestingly, two discharged patients were tested positive again during recovering period and re-admitted to the hospital until nucleic acids tested negative. Screening of underlying diseases shows that all the patients do not have any of the diseases such as autoimmune liver disease, non-alcoholic fatty liver disease, alcoholic fatty liver disease, chronic liver disease, liver failure, acute heart failure, shock, chronic lung diseases, renal insufficiency, immunodeficiency, and hepatitis C.
For details, please refer to online table Table S1. For the 19 patients with fever, peak temperature ranges from When admitted to hospital, body temperature ranges from For detailed information of each patient, please refer to online table Table S4. Clinical characteristics such as breath frequency, blood pressure, heart rate, and blood oxygen saturation were all monitored and recorded. For detailed information of each patient, please refer to online table Table S5. In order to get a better understanding of the clinical features of COVID, we analyzed all the available laboratory test data of the 25 patients comparatively in terms of course of treatment.
Four main of laboratory test involving 42 different indicators were studies, which include route blood test RBTCMP, infection tests, and coagulation tests.
A timeline of events for hospital admission, hospital discharge, PCR test, chest CT scanning, and all the laboratory tests was constructed so as to provide an overview of the whole clinical diagnosis procedures Figure 1. We compared all the available laboratory test for patients at the stages of hospital admission and discharge. According to the analysis, it was found that indicators such as white blood cells [admission 5. In addition, no statistical differences were identified for indicators such as red blood cell [admission 4. However, their average values were out of normal range.
As for other indicators, they were in normal range with no ificant difference at both admission and discharge times. For details, please refer to Table 1. Currently, there is no vaccine or cure for the disease. Since the outbreak of COVID disease from late December,many studies swiftly reported the epidemiological features and clinical findings of the infected patients in different regions of China 11 - 13which greatly facilitate the disease diagnosis and the prevention of the virus spread. In addition, the sex ratio analysis showed that male-to-female ratio was 0. Thus, there seems to be roughly equal s of cases between men and women so far, though sex differences in mortality and vulnerability were observed, that is, men having higher mortality than women with unclear reasons In this study, we summarized the epidemiological features of 25 patients in a single hospital, together with clinical findings in terms of laboratory tests.
According to the 7th edition of the New Coronavirus Pneumonia Diagnosis and Treatment Plan, at the early stage of the disease onset, the total of white blood cells in the peripheral blood was normal or decreased, and the lymphocyte count was decreased. Some patients had increased levels of liver enzymes, lactate dehydrogenase, muscle enzymes, and myoglobin.
Some critically ill patients saw increased troponin. In addition, most patients had elevated C-reactive protein and erythrocyte sedimentation rate and normal procalcitonin. In severe cases, D-dimer may increase, and peripheral blood lymphocytes progressively decrease.
Severe and critically ill patients often have elevated inflammatory factors. It was suggested that decrease of lymphocytes could be due to the functional exhaustion However, the specific reasons were still under investigation In this study, we confirmed that white blood cells, lymphocytes, monocytes, and neutrophils were in normal range during infection, which were all increased after medical treatment, suggesting enhanced immunity and the effects of medical therapy.
It was also noticed that liver Xuzhou sex contacts was associated with SARS-CoV-2 infection with elevated level of lactate dehydrogenase and creatinine, which was more prevalent in severe cases than in mild cases In this study, we observed that the ificant decrease of lactate dehydrogenase for medical treatments, which indicated patients in recovering mode. As for the ificantly raised triglyceride and sodium levels at discharge, it could be due to the diet change and long-term best rest without exercise during hospitalization.
This might also explain the apparent increase of total cholesterol for the patients. As for the C-reactive protein, it was reported to be positively correlated with lung lesions and could reflect disease severity at the early stage of COVID Abnormally high level of C-reactive protein In terms of the coagulation test, two indicators, both INR and PT were ificantly reduced, which was consistent with recent findings that the two indicators were lower in normal group than COVID patients In terms of ferritin, it is a major intracellular iron storage protein in all organisms, which binds free ions of the trace element, neutralizing its toxic properties and increasing its solubility.
High level of ferritin has been associated with increased illness severity and adverse outcomes, including COVID, which might lead to Xuzhou sex contacts storm. In this study, we observed a slightly higher ferritin level on average for patients from admission to discharge. The possible explanations for this abnormality include I the ferritin data for patients from admission to discharge is not complete, which might not reflect the real trend of the indictor and II when patients discharging from hospital, they only need to meet the criteria of no fever, two negative PCR test, and well-orbed lung lesions.
Thus, these patients are still in recovering stage and there might still be some indicators out of normal range. In general, the indicators identified in this study with ificant alterations could be used as assessment of medical therapy during patient recovery. However, it is rather hard to draw any clear correlation with patient recovery time and lab values or treatment strategies. In fact, given the wide variation in treatments, the lab parameters would be uninterpretable without larger cohort sizes.
According to several clinical trials in terms of its efficacy and safety toward SARS-CoV-2 infections, LH capsules could be considered to ameliorate clinical symptoms of Covid and shorten the duration of viral shedding 21 - ly, a bioinformatic analysis constructed an influenza-related protein-protein interaction PPI network, which revealed that there were 15 main effective components in the medicine while 7 of them were further experimentally validated to have antivirus efficacy in vitro As for SARS-CoV-2 infection, it was postulated that key components in LH capsules could block the binding of SARS-CoV-2 with the angiotensin converting enzyme and ameliorate lung injury via the suppression of oxidative stress and apoptosis, though more experimental evidences were required Epidemiological characterization and clinical findings were reported.
In particular, temporal changes in laboratory markers during hospitalization of patients were reported, though the small sample size might not be sufficient to draw generalized conclusions and require further studies. Patients received medical treatments by following the official guide of the New Coronavirus Pneumonia Diagnosis and Treatment Plan and were all discharged home for recovering.
In addition, chest CT scanning showed continuing resolution of lung lesions for these patients. In sum, Xuzhou sex contacts study Xuzhou sex contacts a clinical overview of COVID disease and identified some ificantly altered laboratory markers during SARS-CoV-2 infection through comparative analysis of a small group of patients in a single hospital, which might facilitate clinicians to prevent the transmission of the virus and help diagnose COVID patients at an early stage. We express our special appreciation and thanks to Professor Minglong Chen, Professor Peisheng Jin, and Professor Xianliang Yan for their advices and guidance on this study.
The authors have no conflicts of interest to declare. Ethical Statement: The authors are able for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. The present study was performed in accordance with the Helsinki Declaration as revised in and was approved by the Ethics Committee of the affiliated hospital of Xuzhou Medical University No. All the patients have been discharged home.
Known transmission routes, such as familial clusters and close contacts, were illustrated on the left. The three imported cases were marked with capital letter I. Time points for admission blue dotsdischarge yellow dotschest CT grey dotsPCR green dots for positive and red dots for negativeand laboratory tests RBT, CMP, infection test, coagulation were all specified in the time line.
Ann Transl Med ;9 1Xuzhou sex contacts
email: [email protected] - phone:(329) 997-2871 x 7720
Local Zhenjiang singles looking to hookup and sex